SMAD4

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SMAD4 protein abundance is significantly associated with the RNA expression of many other genes, with 15,418 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMAD4-associated genes across cancer lineages are POLI, DYM, and ELAC1. Each is linked with SMAD4 in more than 9 cancer types. Because this analysis shows association rather than direction, both SMAD4-to-partner and partner-to-SMAD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD4 versus POLI in OV, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD4→partner) and Y-score (partner→SMAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVPOLI →+0.904+0.407<.001<.00139
LSCCDYM →+0.583+0.320<.001<.00139
HNSCELAC1 →+0.529+0.198<.001<.00139
COADHAUS1 →+0.890+0.299<.001<.00139
LSCCSMAD2 →+0.660+0.297<.001<.00139
COADMEX3C →+0.691+0.341<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 15,418 associations by consensus.

SMAD4 vs POLI — OV

Per-sample scatter of SMAD4 vs POLI in OV (Pearson r = 0.60).

Explore this scatter interactively →

Exploration