SMAD4

Across TCGA patient cohorts, SMAD4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMAD4-associated genes across cancer lineages are IGFBP2, Caspase-7-cleavedD198, and alpha-Catenin. Each is linked with SMAD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMAD4-to-partner and partner-to-SMAD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SMAD4-low versus SMAD4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD4→partner) and Y-score (partner→SMAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGFBP2 →	+0.763	+2.115	<.001	.015	3	3
UCEC	Caspase-7-cleavedD198 →	+1.017	+3.807	<.001	<.001	3	3
STAD	alpha-Catenin →	+0.279	+2.584	.004	.009	3	2
COAD	Caveolin-1 →	-0.663	-2.222	.004	.009	3	2
UCEC	Notch1 →	+0.225	+2.916	<.001	<.001	3	2
UCEC	Rab25 →	-0.442	-3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

IGFBP2 by SMAD4 expression — COAD

Explore this box plot interactively →