SMAD2

Across TCGA cell cohorts, SMAD2 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMAD2-associated genes across cancer lineages are XAGE5, RNF125, and GPR63. Each is linked with SMAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD2-to-partner and partner-to-SMAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by SMAD2-low versus SMAD2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD2→partner) and Y-score (partner→SMAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
LARGE_INTESTINE	RNF125 →	+0.841	+3.064	.003	.009	3	1
LARGE_INTESTINE	GPR63 →	+0.732	+3.364	.001	.002	3	1
LARGE_INTESTINE	SNX3 →	+0.488	+3.364	.005	.002	3	1
LARGE_INTESTINE	TCEANC2 →	+0.450	+3.064	<.001	.009	3	1
LARGE_INTESTINE	SDHB →	+0.489	+3.451	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

XAGE5 by SMAD2 expression — OVARY

Explore this box plot interactively →