SMAD1

Across TCGA patient cohorts, SMAD1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,170 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SMAD1-associated genes across cancer lineages are SETD7, SLC10A7, and NEK1. Each is linked with SMAD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMAD1 versus SETD7 in BRCA, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SETD7 →	+0.628	+0.333	<.001	<.001	3	4
OV	SLC10A7 →	+0.531	+0.273	.001	.008	3	3
BRCA	NEK1 →	+0.779	+0.397	<.001	<.001	3	3
UCEC	ZNF280D →	+0.473	+0.459	<.001	.001	3	3
BRCA	CENPC →	+0.690	+0.478	<.001	<.001	3	3
OV	CBR4 →	+0.872	+0.285	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,170 associations by consensus.

SMAD1 vs SETD7 — BRCA

Explore this scatter interactively →