SMAD1-AS1

Across TCGA patient cohorts, SMAD1-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,124 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SMAD1-AS1-associated GO terms across cancer lineages are Protein-containing complex disassembly, Obsolete histone modification, and Obsolete histone methylation. Each is linked with SMAD1-AS1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SMAD1-AS1-to-partner and partner-to-SMAD1-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-containing complex disassembly grouped by SMAD1-AS1-low versus SMAD1-AS1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1-AS1→partner) and Y-score (partner→SMAD1-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein-containing complex disassembly →	+0.044	+0.179	<.001	<.001	3	14
ESCA	Obsolete histone modification →	+0.047	+0.181	<.001	<.001	3	13
LAML	Obsolete histone methylation →	+0.055	+0.705	<.001	<.001	3	13
ESCA	Protein polyubiquitination →	+0.047	+0.183	<.001	<.001	3	13
ESCA	DNA damage response, signal transduction by p53 class mediator →	+0.045	+0.138	<.001	<.001	3	13
ESCA	Obsolete regulation of histone methylation →	+0.052	+0.179	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,124 associations by consensus.

Protein-containing complex disassembly by SMAD1-AS1 expression — ESCA

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