SMAD1-AS1

Across TCGA pan-cancer cohorts, SMAD1-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated SMAD1-AS1 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher SMAD1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMAD1-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LAML show a favorable association.

TGCT, THYM, and LUSC are the cancer types where SMAD1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Tertile	II,III,IV	0.505	1.000	<.001	78	view →
THYM	OS	Tertile	III,IV	0.103	0.944	<.001	63	view →
LUSC	OS	Tertile	III,IV	0.054	0.768	<.001	54	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
THCA	OS	Tertile	All	0.171	0.929	<.001	27	view →
OV	DFS	Quartile	IV	0.253	0.504	.003	16	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	9	view →
ACC	DFS	Tertile	III,IV	0.057	0.457	.040	9	view →
LIHC	DFS	Tertile	II,III,IV	0.134	0.432	.017	9	view →
STAD	DFS	Tertile	IV	0.097	0.412	.008	9	view →
CESC	DFS	Tertile	All	0.955	0.803	.045	6	view →
LGG	DFS	Tertile	All	0.708	0.862	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

SMAD1-AS1–TGCT (OS)

Open the TGCT breakdown →