SLX4IP

Across TCGA patient cohorts, SLX4IP mutation is significantly associated with the RNA expression of many other genes, with 516 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLX4IP-associated genes across cancer lineages are RNF126, LYZ, and RNU6-666P. Each is linked with SLX4IP in more than 1 cancer types. Because this analysis shows association rather than direction, both SLX4IP-to-partner and partner-to-SLX4IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF126 grouped by SLX4IP-low versus SLX4IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLX4IP→partner) and Y-score (partner→SLX4IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNF126 →	+0.456	+2.732	.006	.003	3	2
UCEC	LYZ →	+1.352	+2.711	.005	.003	3	2
LUAD	RNU6-666P →	+0.218	+4.730	.001	.005	3	2
BLCA	RNU6-1113P →	+0.208	+5.632	<.001	.001	3	2
UCEC	TMEM244 →	+0.234	+2.055	<.001	.006	3	2
UCEC	RNU6-338P →	+0.376	+2.572	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 516 associations by consensus.

RNF126 by SLX4IP expression — UCEC

Explore this box plot interactively →