SLX4IP

Across TCGA patient cohorts, SLX4IP mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLX4IP-associated genes across cancer lineages are CD8+ Tcm, CD8+ T-cells, and CD4+ naive T-cells. Each is linked with SLX4IP in more than 3 cancer types. Because this analysis shows association rather than direction, both SLX4IP-to-partner and partner-to-SLX4IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by SLX4IP-low versus SLX4IP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLX4IP→partner) and Y-score (partner→SLX4IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ Tcm →	+0.151	+5.917	<.001	.032	3	4
COAD	CD8+ T-cells →	+0.089	+6.142	<.001	.027	3	2
COAD	CD4+ naive T-cells →	+0.047	+6.142	<.001	.027	3	1
SKCM	Megakaryocytes →	+0.024	+1.957	.028	.028	3	1
UCEC	CD8+ naive T-cells →	+0.026	+3.016	.032	.019	3	1
UCEC	Adipocytes →	+0.017	+2.092	.036	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CD8+ Tcm by SLX4IP expression — COAD

Explore this box plot interactively →