SLX4IP

Across TCGA cell cohorts, SLX4IP mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLX4IP-associated genes across cancer lineages are GTF2B, ING2, and COL6A5. Each is linked with SLX4IP in more than 1 cancer types. Because this analysis shows association rather than direction, both SLX4IP-to-partner and partner-to-SLX4IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF2B grouped by SLX4IP-low versus SLX4IP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLX4IP→partner) and Y-score (partner→SLX4IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GTF2B →	+0.473	+3.215	<.001	.009	3	1
LARGE_INTESTINE	ING2 →	+0.646	+3.067	<.001	.009	3	1
LARGE_INTESTINE	COL6A5 →	+0.321	+3.724	.003	.004	3	1
LARGE_INTESTINE	MRPL30 →	+0.387	+3.215	.006	.009	3	1
LARGE_INTESTINE	MSMO1 →	+1.107	+3.064	<.001	.009	3	1
BLOOD_Leukemia	OTOL1 →	+0.008	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GTF2B by SLX4IP expression — LARGE_INTESTINE

Explore this box plot interactively →