Across TCGA patient cohorts, SLX4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,360 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SLX4-associated genes across cancer lineages are USP30, NEIL3, and CUTC. Each is linked with SLX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLX4-to-partner and partner-to-SLX4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLX4→partner) and Y-score (partner→SLX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP30 →	+0.289	+0.230	.002	.005	3	2
LUAD	NEIL3 →	+0.806	+0.322	<.001	.001	3	2
PDAC	CUTC →	+0.419	+0.804	.002	.001	3	2
PDAC	GPBP1 →	+0.468	+1.041	.005	.006	3	2
LSCC	GABPA →	+0.449	+0.327	.004	.006	3	2
PDAC	PSMA3 →	+0.301	+1.055	.004	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,360 associations by consensus.

Exploration

SLX4 survival (RNA) · tumor vs normal (RNA) · all SLX4 data types