Across TCGA patient cohorts, SLX4 mutation is significantly associated with the RNA expression of many other genes, with 5,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLX4-associated genes across cancer lineages are MELK, DEPDC1, and WDHD1. Each is linked with SLX4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLX4-to-partner and partner-to-SLX4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLX4→partner) and Y-score (partner→SLX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MELK →	+0.478	+1.788	.002	.001	3	6
COAD	DEPDC1 →	+0.812	+2.362	<.001	<.001	3	6
COAD	WDHD1 →	+0.610	+2.820	<.001	.001	3	5
COAD	KIF4A →	+0.403	+1.939	.004	.003	3	5
COAD	CLSPN →	+0.674	+2.999	<.001	<.001	3	5
COAD	RPF1 →	+0.343	+1.952	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,758 associations by consensus.

Exploration

SLX4 survival (RNA) · tumor vs normal (RNA) · all SLX4 data types