Across TCGA cell cohorts, SLX4 mutation is significantly associated with the RNA expression of many other genes, with 1,071 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLX4-associated genes across cancer lineages are EML5, FEM1A, and PLSCR5. Each is linked with SLX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLX4-to-partner and partner-to-SLX4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLX4→partner) and Y-score (partner→SLX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EML5 →	+0.703	+2.265	.005	.001	3	3
BLOOD_Leukemia	FEM1A →	+0.624	+3.366	<.001	.002	3	3
BONE	PLSCR5 →	+0.033	+5.169	<.001	.004	3	2
SOFT_TISSUE	OR9A2 →	+0.023	+2.832	<.001	.005	3	2
LUNG_SCLC	DDI1 →	+0.038	+3.491	<.001	.008	3	2
BREAST	DEFB108B →	+0.088	+3.781	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,071 associations by consensus.

Exploration

SLX4 survival (RNA) · tumor vs normal (RNA) · all SLX4 data types