SLX1A

Across TCGA pan-cancer cohorts, SLX1A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SLX1A data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLX1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLX1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and THYM show a favorable association.

KIRC, KICH, and DLBC are the cancer types where SLX1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.524	0.709	<.001	140	view →
KICH	OS	Median	All	0.815	0.986	<.001	76	view →
DLBC	DFS	Median	III,IV	0.146	0.984	<.001	42	view →
LUAD	DFS	Median	All	0.670	0.837	<.001	40	view →
ACC	OS	Median	All	0.762	0.973	.006	31	view →
HNSC	DFS	Median	III,IV	0.438	0.213	.008	23	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.423	.004	21	view →
PRAD	DFS	Tertile	All	0.836	0.912	.012	18	view →
LGG	DFS	Tertile	All	0.337	0.487	.011	13	view →
THCA	DFS	Median	II,III,IV	0.771	0.902	.007	9	view →
SKCM	OS	Median	IV	0.868	0.290	.020	7	view →
CHOL	DFS	Median	IV	0.082	0.753	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SLX1A–KIRC (DFS)

Open the KIRC breakdown →