SLX1A

Across TCGA pan-cancer cohorts, SLX1A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLX1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLX1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLX1A is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, STAD, and LUSC are the cancer types where SLX1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLX1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.029	<.001	8	view →
STAD	All	All	+0.103	<.001	7	view →
LUSC	All	II,III,IV	+0.044	<.001	6	view →
LIHC	All	II,III,IV	+0.037	<.001	6	view →
COAD	Male	II,III,IV	+0.058	.005	4	view →
KIRC	All	All	+0.010	.023	3	view →
CHOL	Male	All	+0.075	.010	2	view →
BLCA	Male	All	+0.071	.026	2	view →
ESCA	Female	All	+0.133	.047	1	view →
THCA	Female	II,III,IV	−0.032	.003	1	view →
KIRP	Female	All	+0.025	.001	1	view →
LUAD	All	All	+0.025	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLX1A–HNSC

Open the HNSC breakdown →