SLURP1

Across TCGA patient cohorts, SLURP1 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SLURP1-associated genes across cancer lineages are TNPO3P1, MIR494, and RNU6-545P. Each is linked with SLURP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLURP1-to-partner and partner-to-SLURP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNPO3P1 grouped by SLURP1-low versus SLURP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLURP1→partner) and Y-score (partner→SLURP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TNPO3P1 →	+0.047	+4.385	<.001	.008	3	2
UCEC	MIR494 →	+0.404	+4.722	<.001	.004	3	1
UCEC	RNU6-545P →	+0.477	+4.242	<.001	.002	3	1
UCEC	RNU6-792P →	+0.418	+4.722	<.001	.004	3	1
UCEC	RNU6-541P →	+0.477	+3.638	<.001	.006	3	1
UCEC	MIR548O →	+0.648	+3.581	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

TNPO3P1 by SLURP1 expression — SKCM

Explore this box plot interactively →