SLTM

Across TCGA cell cohorts, SLTM mutation is significantly associated with the RNA expression of many other genes, with 262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLTM-associated genes across cancer lineages are NXPE4, DMRTC1B, and SAMM50. Each is linked with SLTM in more than 1 cancer types. Because this analysis shows association rather than direction, both SLTM-to-partner and partner-to-SLTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXPE4 grouped by SLTM-low versus SLTM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLTM→partner) and Y-score (partner→SLTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	2
OVARY	DMRTC1B →	+0.151	+3.959	<.001	<.001	3	2
LARGE_INTESTINE	SAMM50 →	+0.494	+3.234	.004	.004	3	2
LARGE_INTESTINE	ID3 →	+1.859	+2.451	.008	.009	3	2
LARGE_INTESTINE	SCO1 →	+0.798	+3.502	<.001	.001	3	2
LARGE_INTESTINE	CDC73 →	+0.594	+3.169	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

NXPE4 by SLTM expression — BLOOD_Leukemia

Explore this box plot interactively →