SLPI

Across TCGA patient cohorts, SLPI mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SLPI-associated genes across cancer lineages are AQP7P3, OR4H12P, and POLR2L. Each is linked with SLPI in more than 1 cancer types. Because this analysis shows association rather than direction, both SLPI-to-partner and partner-to-SLPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P3 grouped by SLPI-low versus SLPI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLPI→partner) and Y-score (partner→SLPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P3 →	+0.122	+5.582	<.001	.002	3	1
SKCM	OR4H12P →	+0.022	+4.810	<.001	.002	3	1
SKCM	POLR2L →	+0.873	+3.195	<.001	.009	3	1
SKCM	RNU6-525P →	+0.228	+4.219	<.001	.006	3	1
SKCM	RNU6-1104P →	+0.167	+3.213	<.001	.007	3	1
SKCM	SNORD105 →	+0.491	+2.498	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

AQP7P3 by SLPI expression — UCEC

Explore this box plot interactively →