SLN

Across TCGA cell cohorts, SLN RNA expression is significantly associated with the go_rna of many other GO terms, with 780 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SLN-associated GO terms across cancer lineages are Negative regulation of ATPase-coupled calcium transmembrane transporter activity, Negative regulation of calcium ion import into sarcoplasmic reticulum, and Cerebral cortex radially oriented cell migration. Each is linked with SLN in more than 12 cancer types. Because this analysis shows association rather than direction, both SLN-to-partner and partner-to-SLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ATPase-coupled calcium transmembrane transporter activity grouped by SLN-low versus SLN-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLN→partner) and Y-score (partner→SLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of ATPase-coupled calcium transmembrane transporter activity →	+1.280	+3.245	<.001	<.001	3	13
SOFT_TISSUE	Negative regulation of calcium ion import into sarcoplasmic reticulum →	+1.198	+3.085	<.001	<.001	3	13
LUNG_SCLC	Cerebral cortex radially oriented cell migration →	+0.137	+1.622	<.001	.005	3	3
LUNG_NSCLC_LUSC	Bile acid and bile salt transport →	-0.105	-0.146	.003	<.001	3	3
LUNG_NSCLC_LUSC	Regulation of protein localization to microtubule →	-0.116	-0.108	<.001	.002	3	3
LUNG_NSCLC_LUSC	Negative regulation of protein localization to microtubule →	-0.116	-0.108	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 780 associations by consensus.

Negative regulation of ATPase-coupled calcium transmembrane transporter activity by SLN expression — SOFT_TISSUE

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