SLN

Across TCGA pan-cancer cohorts, SLN RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLN data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLN expression acts as an unfavorable survival marker, although some lineages such as READ and CHOL show a favorable association.

KIRC, THCA, and CESC are the cancer types where SLN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.535	0.723	<.001	95	view →
THCA	DFS	Quartile	II,III,IV	0.528	0.833	<.001	90	view →
CESC	OS	Median	All	0.457	0.691	<.001	86	view →
HNSC	OS	Median	II,III,IV	0.686	0.825	.001	58	view →
LIHC	OS	Tertile	All	0.681	0.818	<.001	54	view →
UCEC	OS	Quartile	All	0.889	0.946	.007	42	view →
KICH	DFS	Quartile	III,IV	0.056	0.887	.001	33	view →
THYM	DFS	Median	All	0.805	0.975	.004	27	view →
BLCA	DFS	Tertile	IV	0.230	0.583	.015	24	view →
READ	DFS	Quartile	II,III,IV	0.911	0.697	.006	16	view →
SCLC	DFS	Tertile	All	0.329	0.914	.006	14	view →
TGCT	DFS	Median	All	0.569	0.772	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLN–KIRC (OS)

Open the KIRC breakdown →