SLMAP

Across TCGA patient cohorts, SLMAP mutation is significantly associated with the RNA expression of many other genes, with 1,681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLMAP-associated genes across cancer lineages are TSPY26P, RNA5SP418, and AEN. Each is linked with SLMAP in more than 2 cancer types. Because this analysis shows association rather than direction, both SLMAP-to-partner and partner-to-SLMAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY26P grouped by SLMAP-low versus SLMAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLMAP→partner) and Y-score (partner→SLMAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSPY26P →	-0.567	-1.398	.001	.004	3	3
LUSC	RNA5SP418 →	+0.544	+4.393	<.001	.008	3	3
UCEC	AEN →	+0.452	+2.534	<.001	<.001	3	2
UCEC	MRPS11 →	+0.306	+2.290	<.001	<.001	3	2
UCEC	NOP10 →	+0.385	+2.917	<.001	<.001	3	2
UCEC	CRELD2 →	+0.353	+2.031	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,681 associations by consensus.

TSPY26P by SLMAP expression — UCEC

Explore this box plot interactively →