SLMAP

Across TCGA cell cohorts, SLMAP mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLMAP-associated genes across cancer lineages are ASPN, CALHM4, and PROP1. Each is linked with SLMAP in more than 1 cancer types. Because this analysis shows association rather than direction, both SLMAP-to-partner and partner-to-SLMAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by SLMAP-low versus SLMAP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLMAP→partner) and Y-score (partner→SLMAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.037	+3.426	.004	.007	3	1
BLOOD_Leukemia	CALHM4 →	+0.022	+5.269	.001	<.001	3	1
BLOOD_Leukemia	PROP1 →	+0.032	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR2M3 →	+0.021	+4.409	<.001	.005	3	1
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	CBLL2 →	+0.018	+4.947	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ASPN by SLMAP expression — LARGE_INTESTINE

Explore this box plot interactively →