SLK

Across TCGA pan-cancer cohorts, SLK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLK data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLK expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, OV, and LUAD are the cancer types where SLK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.906	.006	29	view →
OV	DFS	Tertile	All	0.602	1.000	.019	16	view →
LUAD	DFS	Quartile	II,III,IV	0.161	0.801	.004	16	view →
PDAC	OS	Median	II,III,IV	0.630	0.399	.020	12	view →
GBM	DFS	Median	All	0.826	0.550	.002	11	view →
UCEC	DFS	Tertile	All	0.972	0.852	.022	6	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLK–HNSC (DFS)

Open the HNSC breakdown →