SLK

Across TCGA patient cohorts, SLK mutation is significantly associated with the RNA expression of many other genes, with 3,382 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLK-associated genes across cancer lineages are RN7SL578P, CDRT15P3, and MIR1200. Each is linked with SLK in more than 1 cancer types. Because this analysis shows association rather than direction, both SLK-to-partner and partner-to-SLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL578P grouped by SLK-low versus SLK-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLK→partner) and Y-score (partner→SLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
CESC	CDRT15P3 →	+0.068	+4.304	<.001	.003	3	2
CESC	MIR1200 →	+0.404	+5.579	<.001	.001	3	2
LUSC	MFFP3 →	+0.104	+4.532	<.001	.005	3	2
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
BRCA	TRDD1 →	+0.910	+8.057	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,382 associations by consensus.

RN7SL578P by SLK expression — READ

Explore this box plot interactively →