SLK

Across TCGA patient cohorts, SLK mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLK-associated genes across cancer lineages are ACC_pS79, p62 Lck ligand, and Rab25. Each is linked with SLK in more than 1 cancer types. Because this analysis shows association rather than direction, both SLK-to-partner and partner-to-SLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by SLK-low versus SLK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLK→partner) and Y-score (partner→SLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.225	+1.415	.022	.040	3	2
UCEC	p62 Lck ligand →	+0.293	+2.584	.001	<.001	3	2
UCEC	Rab25 →	-0.242	-1.222	.010	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.662	+2.221	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.533	+2.502	<.001	.001	3	2
COAD	FASN →	+0.610	+2.815	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ACC_pS79 by SLK expression — UCEC

Explore this box plot interactively →