SLIT3-AS2

Across TCGA pan-cancer cohorts, SLIT3-AS2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLIT3-AS2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLIT3-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLIT3-AS2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

KIRC, BRCA, and BLCA are the cancer types where SLIT3-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.726	0.840	.001	69	view →
BRCA	OS	Tertile	III,IV	0.973	0.852	<.001	37	view →
BLCA	OS	Tertile	II,III,IV	0.561	0.341	.004	24	view →
ESCA	OS	Quartile	III,IV	0.903	0.391	<.001	24	view →
LIHC	OS	Quartile	All	0.707	0.389	.001	24	view →
THCA	OS	Median	II,III,IV	0.931	1.000	.015	19	view →
STAD	DFS	Median	IV	0.713	0.201	.005	18	view →
UCS	DFS	Median	IV	0.835	0.490	.031	18	view →
MESO	OS	Median	All	0.482	0.310	.019	17	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	16	view →
UVM	DFS	Median	II,III,IV	0.343	0.611	.032	12	view →
KICH	DFS	Tertile	II,III,IV	0.436	0.857	.041	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLIT3-AS2–KIRC (DFS)

Open the KIRC breakdown →