SLIT3-AS2

Across TCGA pan-cancer cohorts, SLIT3-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SLIT3-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLIT3-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types SLIT3-AS2 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and READ are the cancer types where SLIT3-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLIT3-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.739	<.001	11	view →
BLCA	All	All	−0.090	.004	8	view →
READ	Male	All	−0.559	<.001	6	view →
KICH	Female	All	−0.036	.001	5	view →
LUSC	Female	II,III,IV	−0.051	.002	4	view →
CHOL	All	All	−0.230	.004	2	view →
LIHC	All	All	−0.058	.032	2	view →
KIRC	All	IV	+0.023	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SLIT3-AS2–COAD

Open the COAD breakdown →