SLIRP

Across TCGA pan-cancer cohorts, SLIRP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLIRP data layer compared with 30 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLIRP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLIRP expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where SLIRP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.518	0.896	.009	27	view →
COAD	DFS	Tertile	All	1.000	0.864	.040	12	view →
LUAD	DFS	Tertile	III,IV	0.962	0.412	.031	6	view →
LSCC	DFS	Tertile	II,III,IV	0.887	0.550	.027	6	view →
PDAC	OS	Median	IV	0.491	0.836	.024	4	view →
UCEC	DFS	Quartile	III,IV	1.000	0.288	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLIRP–HNSC (DFS)

Open the HNSC breakdown →