SLIRP

Across TCGA pan-cancer cohorts, SLIRP mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SLIRP’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SLIRP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLIRP is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where SLIRP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLIRP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.885	<.001	12	view →
COAD	Male	III,IV	+0.576	<.001	10	view →
LUAD	Female	II,III,IV	+0.657	<.001	9	view →
LSCC	Male	All	+1.001	<.001	8	view →
OV	All	All	+0.523	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SLIRP–CCRCC

Open the CCRCC breakdown →