SLFN5

Across TCGA pan-cancer cohorts, SLFN5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLFN5 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLFN5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLFN5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where SLFN5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.985	0.416	.008	28	view →
COAD	DFS	Tertile	All	0.923	1.000	.037	12	view →
LUAD	DFS	Quartile	All	0.809	0.472	.005	12	view →
CCRCC	OS	Tertile	II,III,IV	0.939	0.619	.011	8	view →
LSCC	DFS	Tertile	All	0.897	1.000	.008	7	view →
GBM	OS	Quartile	All	0.729	0.359	.016	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLFN5–HNSC (DFS)

Open the HNSC breakdown →