SLFN5

Across TCGA cell cohorts, SLFN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,971 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SLFN5-associated GO terms across cancer lineages are Intracellular receptor signaling pathway, Regulation of cytokine-mediated signaling pathway, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with SLFN5 in more than 14 cancer types. Because this analysis shows association rather than direction, both SLFN5-to-partner and partner-to-SLFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular receptor signaling pathway grouped by SLFN5-low versus SLFN5-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN5→partner) and Y-score (partner→SLFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Intracellular receptor signaling pathway →	+0.067	+2.149	<.001	<.001	3	15
CNS	Regulation of cytokine-mediated signaling pathway →	+0.077	+2.048	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.106	+1.921	<.001	<.001	3	14
BREAST	Urokinase plasminogen activator signaling pathway →	+0.787	+1.120	.001	.004	2	15
URINARY_TRACT	Positive regulation of innate immune response →	+0.053	+1.363	.002	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of protein export from nucleus →	+0.129	+1.651	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,971 associations by consensus.

Intracellular receptor signaling pathway by SLFN5 expression — SOFT_TISSUE

Explore this box plot interactively →