SLFN5

Across TCGA cell cohorts, SLFN5 mutation is significantly associated with the RNA expression of many other genes, with 410 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLFN5-associated genes across cancer lineages are OR10W1, RTP1, and GDF3. Each is linked with SLFN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN5-to-partner and partner-to-SLFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by SLFN5-low versus SLFN5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN5→partner) and Y-score (partner→SLFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10W1 →	+0.008	+4.196	<.001	.006	3	2
LUNG_NSCLC_LUAD	RTP1 →	+0.064	+3.866	<.001	.006	3	2
LUNG_NSCLC_LUAD	GDF3 →	+0.017	+4.078	<.001	.009	3	2
BREAST	BANF2 →	+0.256	+3.672	<.001	.006	3	1
BREAST	C20orf173 →	+0.179	+3.758	<.001	.007	3	1
BREAST	SPATA16 →	+0.011	+3.672	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 410 associations by consensus.

OR10W1 by SLFN5 expression — BREAST

Explore this box plot interactively →