SLFN12L

Across TCGA cell cohorts, SLFN12L mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLFN12L-associated genes across cancer lineages are DEFB124, UTF1, and WSCD2. Each is linked with SLFN12L in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN12L-to-partner and partner-to-SLFN12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by SLFN12L-low versus SLFN12L-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12L→partner) and Y-score (partner→SLFN12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	1
LARGE_INTESTINE	UTF1 →	+0.015	+3.632	<.001	.003	3	1
LARGE_INTESTINE	WSCD2 →	+0.148	+3.660	<.001	.005	3	1
BLOOD_Leukemia	SLITRK3 →	+0.035	+3.874	<.001	.005	3	1
BLOOD_Leukemia	UGT2B4 →	+0.051	+3.855	.001	.007	3	1
BLOOD_Leukemia	S100A7A →	+0.037	+4.567	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

DEFB124 by SLFN12L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →