SLFN12

Across TCGA patient cohorts, SLFN12 mutation is significantly associated with the RNA expression of many other genes, with 1,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN12-associated genes across cancer lineages are MIR4662B, PRAMEF13, and MT1HL1. Each is linked with SLFN12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLFN12-to-partner and partner-to-SLFN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4662B grouped by SLFN12-low versus SLFN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12→partner) and Y-score (partner→SLFN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4662B →	+0.167	+3.292	<.001	.003	3	3
LGG	PRAMEF13 →	+0.044	+7.977	<.001	.007	3	2
SKCM	MT1HL1 →	+0.085	+2.196	.001	.003	3	2
UCEC	LINC02340 →	+0.355	+2.804	<.001	.002	3	2
READ	VN1R90P →	+0.171	+5.039	<.001	.008	3	2
LUAD	RN7SL339P →	+0.189	+5.217	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,226 associations by consensus.

MIR4662B by SLFN12 expression — UCEC

Explore this box plot interactively →