SLFN11

Across TCGA cell cohorts, SLFN11 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLFN11-associated genes across cancer lineages are GHRH, OR2C1, and GDF3. Each is linked with SLFN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by SLFN11-low versus SLFN11-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.098	+3.725	.003	.008	3	1
BREAST	GDF3 →	+0.146	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	OTOP1 →	+0.011	+3.215	.003	.007	3	1
LUNG_NSCLC_LUAD	MOGAT2 →	+0.196	+3.836	<.001	.006	3	1
LUNG_NSCLC_LUAD	MROH2B →	+0.394	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

GHRH by SLFN11 expression — OESOPHAGUS

Explore this box plot interactively →