SLF2

Across TCGA pan-cancer cohorts, SLF2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLF2 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SLF2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLF2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where SLF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.232	0.840	<.001	23	view →
CCRCC	DFS	Median	All	1.000	0.488	.026	2	view →
LSCC	DFS	Quartile	All	1.000	0.515	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLF2–LUAD (DFS)

Open the LUAD breakdown →