SLF2

Across TCGA pan-cancer cohorts, SLF2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SLF2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SLF2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLF2 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where SLF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.830	<.001	11	view →
KIRC	Male	All	+0.537	<.001	11	view →
HNSC	All	II,III,IV	+0.423	.001	10	view →
LIHC	Female	II,III,IV	+1.475	<.001	9	view →
KICH	All	All	−0.683	<.001	5	view →
STAD	All	II,III,IV	+0.669	.010	4	view →
BRCA	All	II,III,IV	+0.271	<.001	4	view →
CHOL	All	All	+1.866	<.001	3	view →
BLCA	Female	III,IV	+0.582	.036	3	view →
UCEC	All	All	−0.588	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SLF2–KIRP

Open the KIRP breakdown →