SLF2

Across TCGA patient cohorts, SLF2 mutation is significantly associated with the RNA expression of many other genes, with 3,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLF2-associated genes across cancer lineages are SEMG2, RN7SL25P, and RPL32P19. Each is linked with SLF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLF2-to-partner and partner-to-SLF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by SLF2-low versus SLF2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLF2→partner) and Y-score (partner→SLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEMG2 →	+0.460	+4.292	<.001	.003	3	3
READ	RN7SL25P →	+0.229	+4.925	<.001	.004	3	3
KIRP	RPL32P19 →	+0.061	+4.628	<.001	.007	3	3
UCEC	PARG →	+0.374	+1.484	.007	.004	3	3
UCEC	ICE2 →	+0.492	+1.979	<.001	<.001	3	3
UCEC	KIF23 →	+0.528	+2.343	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,535 associations by consensus.

SEMG2 by SLF2 expression — BRCA

Explore this box plot interactively →