SLF2

Across TCGA patient cohorts, SLF2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLF2-associated genes across cancer lineages are ERK2, Ku80, and p27_pT157. Each is linked with SLF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLF2-to-partner and partner-to-SLF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLF2-low versus SLF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLF2→partner) and Y-score (partner→SLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.131	+1.392	.039	.019	3	2
UCEC	Ku80 →	+0.244	+1.857	.001	.004	3	2
UCEC	p27_pT157 →	-0.046	-2.048	.015	.005	3	2
UCEC	p70-S6K_pT389 →	-0.195	-1.584	.001	.032	3	2
UCEC	PCNA →	+0.198	+1.584	.005	.017	3	2
UCEC	Shc_pY317 →	-0.169	-1.652	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ERK2 by SLF2 expression — UCEC

Explore this box plot interactively →