SLF2

Across TCGA cell cohorts, SLF2 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLF2-associated genes across cancer lineages are C12orf57, SELENOK, and ARL1. Each is linked with SLF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLF2-to-partner and partner-to-SLF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf57 grouped by SLF2-low versus SLF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLF2→partner) and Y-score (partner→SLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf57 →	+0.745	+3.169	.007	.009	3	1
LARGE_INTESTINE	SELENOK →	+0.531	+3.502	.003	.001	3	1
LARGE_INTESTINE	ARL1 →	+0.531	+3.064	.001	.009	3	1
LARGE_INTESTINE	ULBP3 →	+0.814	+3.234	.004	.004	3	1
LARGE_INTESTINE	EMC7 →	+0.577	+3.502	<.001	.001	3	1
LARGE_INTESTINE	RTCA →	+0.589	+2.537	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

C12orf57 by SLF2 expression — LARGE_INTESTINE

Explore this box plot interactively →