SLF1

Across TCGA patient cohorts, SLF1 mutation is significantly associated with the RNA expression of many other genes, with 4,097 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLF1-associated genes across cancer lineages are RNU6-1201P, NRBP2, and EMID1. Each is linked with SLF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLF1-to-partner and partner-to-SLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1201P grouped by SLF1-low versus SLF1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLF1→partner) and Y-score (partner→SLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-1201P →	+0.439	+4.776	<.001	.003	3	2
COAD	NRBP2 →	-0.760	-3.459	<.001	.005	3	2
UCEC	EMID1 →	-1.191	-2.652	<.001	<.001	3	2
COAD	SDHD →	+0.637	+3.459	.004	.005	3	2
COAD	LIN52 →	+0.528	+3.472	<.001	.002	3	2
COAD	PPP2R2A →	+0.572	+3.199	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,097 associations by consensus.

RNU6-1201P by SLF1 expression — LIHC

Explore this box plot interactively →