SLF1

Across TCGA pan-cancer cohorts, SLF1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SLF1 data layer compared with 12 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SLF1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLF1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRP, KIRC, and KICH are the cancer types where SLF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.644	0.788	.002	76	view →
KIRC	DFS	Median	All	0.749	0.492	<.001	73	view →
KICH	DFS	Tertile	II,III,IV	0.403	0.937	<.001	61	view →
LGG	OS	Median	All	0.703	0.912	<.001	54	view →
LIHC	DFS	Median	All	0.461	0.622	<.001	45	view →
SKCM	DFS	Quartile	All	0.227	0.114	.005	42	view →
LUAD	OS	Median	All	0.764	0.857	<.001	40	view →
READ	OS	Quartile	All	0.886	0.368	.007	30	view →
HNSC	DFS	Quartile	All	0.799	0.646	.006	20	view →
UVM	DFS	Tertile	III,IV	0.279	0.806	.008	19	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →
THYM	OS	Median	II,III,IV	1.000	0.643	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SLF1–KIRP (DFS)

Open the KIRP breakdown →