SLF1

Across TCGA patient cohorts, SLF1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLF1-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and Rad50. Each is linked with SLF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLF1-to-partner and partner-to-SLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLF1-low versus SLF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLF1→partner) and Y-score (partner→SLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.411	-1.575	.004	.017	3	3
UCEC	EGFR_pY1068 →	-0.280	-1.893	<.001	<.001	3	2
UCEC	Rad50 →	-0.177	-1.201	.018	.028	3	2
UCEC	Annexin-1 →	+0.669	+3.169	<.001	<.001	3	2
UCEC	ASNS →	+0.436	+1.765	<.001	.011	3	2
UCEC	ATM →	-0.448	-1.643	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDCD4 by SLF1 expression — UCEC

Explore this box plot interactively →