SLF1

Across TCGA cell cohorts, SLF1 mutation is significantly associated with the RNA expression of many other genes, with 272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLF1-associated genes across cancer lineages are OR56A5, GGT2, and KRTAP6-1. Each is linked with SLF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLF1-to-partner and partner-to-SLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by SLF1-low versus SLF1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLF1→partner) and Y-score (partner→SLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	2
SKIN	GGT2 →	+0.106	+3.920	<.001	.005	3	1
SKIN	KRTAP6-1 →	+0.060	+4.437	<.001	.004	3	1
SKIN	RTP2 →	+0.018	+4.217	<.001	.001	3	1
SKIN	OR51A4 →	+0.008	+4.437	<.001	.004	3	1
SKIN	SERPINA2 →	+0.019	+3.684	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 272 associations by consensus.

OR56A5 by SLF1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →