SLCO5A1

Across TCGA patient cohorts, SLCO5A1 mutation is significantly associated with the RNA expression of many other genes, with 3,498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO5A1-associated genes across cancer lineages are CHAF1B, OIP5, and CDCA2. Each is linked with SLCO5A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLCO5A1-to-partner and partner-to-SLCO5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1B grouped by SLCO5A1-low versus SLCO5A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO5A1→partner) and Y-score (partner→SLCO5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1B →	+0.467	+1.601	<.001	.001	3	5
UCEC	OIP5 →	+0.625	+1.523	<.001	<.001	3	4
UCEC	CDCA2 →	+0.705	+2.400	<.001	<.001	3	4
SKCM	ZFYVE19 →	+0.317	+2.372	<.001	.002	3	4
LUSC	SLC38A7 →	+0.516	+3.459	.003	.005	3	3
UCEC	CCL5 →	+1.378	+2.060	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,498 associations by consensus.

CHAF1B by SLCO5A1 expression — UCEC

Explore this box plot interactively →