SLCO1B3

Across TCGA patient cohorts, SLCO1B3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1B3-associated genes across cancer lineages are STAT3_pY705, Cyclin-B1, and eIF4G. Each is linked with SLCO1B3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO1B3-to-partner and partner-to-SLCO1B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SLCO1B3-low versus SLCO1B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B3→partner) and Y-score (partner→SLCO1B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.425	-2.584	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.711	+2.201	<.001	<.001	3	3
UCEC	eIF4G →	+0.322	+3.459	.001	.005	3	2
UCEC	Ku80 →	+0.239	+1.598	.002	.006	3	2
SKCM	Bap1-c-4 →	+0.272	+2.392	.001	<.001	3	2
UCEC	Caspase-8 →	-0.284	-3.295	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

STAT3_pY705 by SLCO1B3 expression — UCEC

Explore this box plot interactively →