SLCO1B3

Across TCGA cell cohorts, SLCO1B3 mutation is significantly associated with the RNA expression of many other genes, with 202 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO1B3-associated genes across cancer lineages are HACD1, MAGEB4, and C20orf173. Each is linked with SLCO1B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1B3-to-partner and partner-to-SLCO1B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HACD1 grouped by SLCO1B3-low versus SLCO1B3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B3→partner) and Y-score (partner→SLCO1B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HACD1 →	+1.214	+3.212	.004	.006	3	2
LARGE_INTESTINE	MAGEB4 →	+0.007	+2.678	.001	.005	3	2
OVARY	C20orf173 →	+0.020	+4.029	.005	.009	3	1
OVARY	ACSM2A →	+0.050	+4.029	.002	.009	3	1
SKIN	MAPK8 →	+0.562	+3.212	.008	.006	3	1
SKIN	GOLGA8J →	+0.046	+3.847	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 202 associations by consensus.

HACD1 by SLCO1B3 expression — SKIN

Explore this box plot interactively →