SLCO1A2

Across TCGA patient cohorts, SLCO1A2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1A2-associated genes across cancer lineages are AR, ERK2, and MYH11. Each is linked with SLCO1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1A2-to-partner and partner-to-SLCO1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by SLCO1A2-low versus SLCO1A2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1A2→partner) and Y-score (partner→SLCO1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	AR →	+0.158	+3.468	.014	.002	3	2
SKCM	ERK2 →	+0.175	+1.415	.026	.045	3	2
SKCM	MYH11 →	-0.727	-2.169	.024	.003	3	2
SKCM	TIGAR →	+0.133	+3.338	.005	.004	3	2
SKCM	Bim →	-0.265	-2.459	.007	.017	3	2
UCEC	Snail →	-0.210	-1.999	.039	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

AR by SLCO1A2 expression — LUSC

Explore this box plot interactively →