SLCO1A2

Across TCGA pan-cancer cohorts, SLCO1A2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLCO1A2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SLCO1A2 RNA is repressed in tumor relative to normal tissue. In most cancer types SLCO1A2 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, HNSC, and KIRC are the cancer types where SLCO1A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLCO1A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−1.585	<.001	11	view →
HNSC	All	III,IV	+0.600	<.001	10	view →
KIRC	Male	All	−0.588	<.001	9	view →
KICH	Male	All	−1.309	<.001	7	view →
BLCA	All	All	+0.724	.001	7	view →
BRCA	Female	All	−0.778	<.001	6	view →
THCA	All	II,III,IV	−0.032	<.001	6	view →
STAD	All	All	+0.181	.006	5	view →
COAD	All	III,IV	+0.084	.012	5	view →
PRAD	All	All	+0.641	.001	2	view →
UCEC	All	All	+0.054	.045	2	view →
LIHC	Female	II,III,IV	−0.509	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLCO1A2–LUAD

Open the LUAD breakdown →