SLCO1A2

Across TCGA cell cohorts, SLCO1A2 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO1A2-associated genes across cancer lineages are SIGLEC6, LCE3D, and HEPACAM. Each is linked with SLCO1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1A2-to-partner and partner-to-SLCO1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC6 grouped by SLCO1A2-low versus SLCO1A2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1A2→partner) and Y-score (partner→SLCO1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIGLEC6 →	+0.095	+3.256	<.001	.005	3	1
LUNG_SCLC	LCE3D →	+0.065	+3.232	<.001	.008	3	1
LUNG_SCLC	HEPACAM →	+0.059	+3.906	<.001	.002	3	1
CNS	SCGB1C1 →	+0.294	+4.981	<.001	.008	3	1
CNS	GUCA2B →	+0.064	+4.981	<.001	.008	3	1
LARGE_INTESTINE	MIER2 →	+0.664	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

SIGLEC6 by SLCO1A2 expression — LUNG_SCLC

Explore this box plot interactively →