SLC9A7

Across TCGA patient cohorts, SLC9A7 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A7-associated genes across cancer lineages are XBP1, MEK1, and ATM. Each is linked with SLC9A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC9A7-to-partner and partner-to-SLC9A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by SLC9A7-low versus SLC9A7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A7→partner) and Y-score (partner→SLC9A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	+0.373	+3.000	.007	.036	3	2
UCEC	MEK1 →	+0.340	+2.700	.004	.005	3	2
UCEC	ATM →	-0.345	-2.000	.021	.009	3	2
UCEC	C-Raf →	+0.093	+1.584	.047	.034	3	2
UCEC	Cyclin-B1 →	+0.475	+1.392	.010	.019	3	2
COAD	Shc_pY317 →	-0.214	-2.991	.013	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

XBP1 by SLC9A7 expression — SKCM

Explore this box plot interactively →